Yes, there is. Countries such as India, Russia, Brazil, China, Indonesia, Malaysia, Nigeria, Qatar, Saudi Arabia, South Africa, and Vietnam, to name a few, do not have an E-2 treaty visa signed with the United States. Therefore, citizens of such countries cannot apply for the E-2 visa directly. They can nevertheless apply for an E-2 visa by becoming a citizen of another country with an E-2 treaty with the United States, such as Grenada, Turkey, or Montenegro. To the best of our knowledge, none of these countries have an issue with dual citizenship. Therefore, later on, if the investor wishes to proceed with an EB-5 application, there should not be a problem.